Abstract: The bioactive compounds and antioxidant activity of the fruits and leaves of Rosa sterilis D. Shi in Guizhou province were analyzed using correlation analysis. The results indicated that gallic acid, rutin, quercetin, catechin, ellagic acid, chlorogenic acid, and ferulic acid were the major phenolic compounds in the fruits and leaves. The contents of bioactive compounds were significantly different between the fruit and leaves (P<0.05). The contents of p-coumaric acid, polyphenols and flavonoids were the highest in the fruit. However, the contents of gallic acid, catechin, chlorogenic acid, epicatechin, ferulic acid, ellagic acid, rutin, quercetin and polyphenols were higher in the leaves. The antioxidant activities of fruit were significantly higher than that of the leaves (P<0.05), flavonoids had a strong contribution to the total reducing power assay (TRPA) value, ascorbic acid had a strong contribution to the ferric ion reducing antioxidant power (FRAP) value, and quercetin had a strong contribution to the ABTS value. The fruits and leaves of R. sterilis D. Shi are of high value for the development of medicinal and edible resources.