Abstract: Interactions between plant nutrient elements and the mechanism of action have been the focus of important research. Boron (B) is an essential element for plants. In recent years, research on the correlation between boron and other elements has achieved a series of results. This article reviews the current research progress on plant morphology, metabonomics, and the cross-linking mechanism in the cell wall pectin network under different B and calcium (Ca) conditions. Furthermore, the use of metabonomics in determining the interaction mechanism between B and Ca on plant growth and development, especially research on the interaction mechanism between the two in the cell wall, are also prospected.