秦岭地区玉竹根茎的脂溶性成分及其抑菌活性研究

Hydrophobic Constituents of Polygonatum odoratum Rhizome from the Qinling Mountains and Their Antisepsis Activity

摘要: 从秦岭产玉竹(Polygonatum odoratum)根茎的石油醚萃取物中分离得到8个化合物,其中有5个化合物为首次从黄精属植物中得到,其结构分别为:(1)(24R/S)-9,19-环阿尔廷-25-烯-3β,24-二醇;(2)α-棕榈酸甘油酯;(3)棕榈酸甲酯;(4)二十八碳酸;(5)(Z)-6-十九碳烯酸。首次对化合物1的抗菌活性进行了测定,发现化合物1在浓度为10μg/mL时,对黄瓜炭疽病原菌的抑制率达到100%;在浓度为100μg/mL时,对灵杆菌的抑菌能力与红霉素相当。

Abstract: Eight compounds were isolated from the rhizomes of Polygonatum odoratum.Five compounds were isolated from the Polygonatum genus for the first time and their structures were identified as 9,19-cycloart-25-en-3β,24(R/S)-diol(1),α-glycerol palmitate(2),methyl palmitate(3),octacosanoic acid(4),(Z)-6-nonadecenoic acid(5).The antisepsis activity of compound 1 was determined for the first time.Compound 1 had a strong inhibition effect on the growth of Colletotrichum lagenarium with an inhibition rate 100% at a concentration of 10 μg/mL.Its inhibition effect corresponded to erythromycin against Bacterium prodigious growth at a concentration of 100 μg/mL.