Epigenetic regulation of root stem cells in plants
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摘要: 干细胞是一类具有特化为不同细胞类型能力的多能性细胞，他为多细胞生物的器官发生、损伤修复和再生源源不断提供新细胞。干细胞的特化和维持需要复杂的基因调控网络来有序调控。此外，表观遗传调控在包括干细胞命运决定在内的许多生物学过程中发挥极其重要的作用。本文归纳了近年来对植物，主要是模式植物拟南芥（Arabidopsis thaliana（L.）Heynh.）根尖干细胞表观遗传调控方面的研究进展，重点论述了表观调控因子与控制干细胞的关键转录因子之间如何互作、调控植物根尖干细胞的自我更新和分化，并对今后研究的突破方向进行了展望。Abstract: Stem cells are a group of pluripotent cells that can differentiate into a diverse range of specialized cell types. They continuously provide new cells for organogenesis, wound repair, and regeneration in multicellular organisms. Stem cell specification and differentiation are orchestrated by complex gene regulatory networks. In addition, epigenetic regulation plays a crucial role in many biological events, including stem cell determination. In this review, we summarize recent advances in epigenetic control of root stem cells in the model plant Arabidopsis thaliana. Specifically, we focus on the interplay between epigenetic regulators and stem cell-controlling key transcription factors, which regulates root stem cell self-renewal and differentiation in plants.
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Keywords:
- Root stem cell /
- Epigenetic regulation /
- Chromatin modification /
- Pluripotency
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