Extracellular adenosine 5'-triphosphate mediates oxidative stress and cell death under cadmium stress by nitric oxide

Shi Zhen-Zhen; Da Meng-Ting; Pang Hai-Long; Jia Ling-Yun; Sun Kun; Feng Han-Qing

doi:10.11913/PSJ.2095-0837.2020.20269

Plant Science Journal > 2020 > 38(2): 269-277. > DOI: 10.11913/PSJ.2095-0837.2020.20269 CSTR: 32231.14.PSJ.2095-0837.2020.20269

Shi Zhen-Zhen, Da Meng-Ting, Pang Hai-Long, Jia Ling-Yun, Sun Kun, Feng Han-Qing. Extracellular adenosine 5'-triphosphate mediates oxidative stress and cell death under cadmium stress by nitric oxide[J]. Plant Science Journal, 2020, 38(2): 269-277. DOI: 10.11913/PSJ.2095-0837.2020.20269

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Extracellular adenosine 5'-triphosphate mediates oxidative stress and cell death under cadmium stress by nitric oxide

College of Life Science, Northwest Normal University, Lanzhou 730070, China

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This work was supported by grants from the National Natural Science Foundation of China (31870246, 31260059), University Scientific Research Project of Gansu Province (2015A-007), Key Research and Development Project of Gansu Province (18YF1NA051), Fundamental Research Funds for the Gansu Universities of Gansu Provincial Department of Finance, and Youth Innovation Team of Northwest Normal University.

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Received Date: July 30, 2019
Revised Date: September 27, 2019
Available Online: October 31, 2022
Published Date: April 27, 2020

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Abstract

Abstract

Cadmium (Cd) is one of the most bio-toxic heavy metals. Extracellular adenosine 5'-triphosphate (ex ATP) is an important signaling molecule involved in regulating physio-logical processes in cells. This study showed that Cd ions (Cd²⁺) increased oxidative stress and death level of Nicotiana tabacum L. suspension cells in a concentration-dependent manner. Conversely, application of exogenous ATP effectively alleviated the increase in Cd²⁺-induced oxidative stress and cell death. Furthermore, similar to the above-mentioned mitigation effects of exogenous ATP, SNP (a nitric oxide donor) also alleviated the increase in Cd²⁺-induced oxidative stress and cell death levels. Moreover, NO synthesis inhibitor (L-NAME) partially relieved the alleviating effects of exogenous ATP. These results indicate that ex ATP regulates Cd-induced oxidative stress and cell death by NO.
- Cd induce,
- Extracellular ATP,
- Nitric oxide,
- Oxidative stress,
- Cell death

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References

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Extracellular adenosine 5'-triphosphate mediates oxidative stress and cell death under cadmium stress by nitric oxide

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