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Wu Ying-Mei, Liao Qing-Gang, Shang Yi, Gong Zhen-Ping, Gou Jun-Bo. Recent progress of paclitaxel biosynthesis aided by multi-omics[J]. Plant Science Journal, 2022, 40(6): 853-866. DOI: 10.11913/PSJ.2095-0837.2022.60853
Citation: Wu Ying-Mei, Liao Qing-Gang, Shang Yi, Gong Zhen-Ping, Gou Jun-Bo. Recent progress of paclitaxel biosynthesis aided by multi-omics[J]. Plant Science Journal, 2022, 40(6): 853-866. DOI: 10.11913/PSJ.2095-0837.2022.60853
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Recent progress of paclitaxel biosynthesis aided by multi-omics

  • 1. School of Life Science, The AGISCAAS-YNNU Joint Academy of Potato Sciences, Yunnan Normal University, Yunnan Key Laboratory of Potato Biology, Kunming 650500, China;

  • 2. Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Shenzhen Key Laboratory of Agricultural Synthetic Biology, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, Guangdong 518124, China;

  • 3. Tangshan Academy of Agricultural Sciences, Tangshan, Hebei 063001, China

Funds: 

This work was supported by grants from the National Natural Science Foundation of China (32000236) and the National Key R&D Program of China (2019YFA09006200).

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  • Received Date: June 06, 2022
  • Revised Date: July 17, 2022
  • Available Online: January 12, 2023
    Graphical Abstract
    • Abstract
  • Taxol (generic name paclitaxel) is a highly effective anti-cancer agent widely used in the clinical treatment of various cancers. At present, the production of paclitaxel is primarily based on artificial semi-synthesis from extracted intermediates (such as baccatin Ⅲ). This commercial method still relies on Taxus plant resources, resulting in high medical costs. The rise of synthetic biology provides a novel approach to acquire sufficient paclitaxel, but research on its biosynthesis is yet to be advanced. Recently, multi-omics approaches have been applied in biosynthesis research on paclitaxel. In the present paper, we review recent progress on the biosynthesis, regulation, and heterologous production of paclitaxel aided by multi-omics, providing new insights into paclitaxel biosynthesis.
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    • References (82)
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